33,787 XNAS Volume
XNAS 14 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Charles S. Ryan | PRESIDENT | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Jan 2025 | 300,000 | 300,000 | - | - | Employee Stock Option (right to buy) | |
| Dirk Thye | Director, CEO AND CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Jan 2025 | 1,200,000 | 1,200,000 | - | - | Employee Stock Option (right to buy) | |
| Brendan Hannah | CBO, COO and CCO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Jan 2025 | 450,000 | 450,000 | - | - | Employee Stock Option (right to buy) | |
| Christopher J. Senner | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 35,274 | 35,274 | - | - | Director Stock Option (right to buy) | |
| David A. Lamond | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 47,587 | 47,587 | - | - | Director Stock Option (right to buy) | |
| Margaret A. McLoughlin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 31,613 | 31,613 | - | - | Director Stock Option (right to buy) | |
| June Bray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 30,282 | 30,282 | - | - | Director Stock Option (right to buy) | |
| Dirk Thye | Director, CEO AND CHIEF MEDICAL OFFICER | Purchase of securities on an exchange or from another person at price $ 0.70 per share. | 29 Aug 2024 | 77,000 | 843,941 (2%) | 0% | 0.7 | 53,900 | Common Stock |
| Dirk Thye | Director, CEO AND CHIEF MEDICAL OFFICER | Purchase of securities on an exchange or from another person at price $ 0.69 per share. | 29 Aug 2024 | 77,500 | 766,941 (2%) | 0% | 0.7 | 53,475 | Common Stock |
| Charles S. Ryan | PRESIDENT | Purchase of securities on an exchange or from another person at price $ 0.65 per share. | 20 Aug 2024 | 48,387 | 122,461 (0%) | 0% | 0.7 | 31,452 | Common Stock |
| Brendan Hannah | CHIEF BUSINESS OFFICER AND COO | Purchase of securities on an exchange or from another person at price $ 0.58 per share. | 19 Aug 2024 | 2,155 | 259,771 (0%) | 0% | 0.6 | 1,250 | Common Stock |
| Brendan Hannah | CHIEF BUSINESS OFFICER AND COO | Purchase of securities on an exchange or from another person at price $ 0.63 per share. | 19 Aug 2024 | 23,565 | 296,540 (1%) | 0% | 0.6 | 14,846 | Common Stock |
| Brendan Hannah | CHIEF BUSINESS OFFICER AND COO | Purchase of securities on an exchange or from another person at price $ 0.62 per share. | 19 Aug 2024 | 5,000 | 272,975 (0%) | 0% | 0.6 | 3,100 | Common Stock |
| Brendan Hannah | CHIEF BUSINESS OFFICER AND COO | Purchase of securities on an exchange or from another person at price $ 0.61 per share. | 19 Aug 2024 | 2,280 | 267,975 (0%) | 0% | 0.6 | 1,391 | Common Stock |
| Brendan Hannah | CHIEF BUSINESS OFFICER AND COO | Purchase of securities on an exchange or from another person at price $ 0.60 per share. | 19 Aug 2024 | 3,424 | 265,695 (0%) | 0% | 0.6 | 2,054 | Common Stock |
| Brendan Hannah | CHIEF BUSINESS OFFICER AND COO | Purchase of securities on an exchange or from another person at price $ 0.61 per share. | 19 Aug 2024 | 2,500 | 262,271 (0%) | 0% | 0.6 | 1,525 | Common Stock |
| Una S. Ryan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 27,000 | 27,000 | - | - | Employee Stock Option (right to buy) | |
| Luca Benatti | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 27,000 | 27,000 | - | - | Employee Stock Option (right to buy) | |
| Rajiv Patni | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 13,500 | 13,500 | - | - | Employee Stock Option (right to buy) | |
| Christopher J. Senner | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 27,000 | 27,000 | - | - | Employee Stock Option (right to buy) | |
| David A. Lamond | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 27,000 | 27,000 | - | - | Employee Stock Option (right to buy) | |
| Margaret McLoughlin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 27,000 | 27,000 | - | - | Employee Stock Option (right to buy) | |
| June Bray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 27,000 | 27,000 | - | - | Employee Stock Option (right to buy) | |
| Brendan Hannah | CHIEF BUSINESS OFFICER AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Jun 2024 | 56,061 | 47,439 | - | - | Employee Stock Option (right to buy) | |
| Brendan Hannah | CHIEF BUSINESS OFFICER AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.55 per share. | 04 Jun 2024 | 56,061 | 257,616 (0%) | 0% | 0.6 | 30,834 | Common Stock |
| Patni Rajiv | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Feb 2024 | 54,000 | 54,000 | - | - | Employee Stock Option (right to buy) | |
| Dirk Thye | Director, CEO AND CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2024 | 1,500,000 | 1,500,000 | - | - | Employee Stock Option (right to buy) | |
| Charles S. Ryan | PRESIDENT | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2024 | 145,000 | 145,000 | - | - | Employee Stock Option (right to buy) | |
| Brendan Hannah | CHIEF BUSINESS OFFICER AND COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2024 | 600,000 | 600,000 | - | - | Employee Stock Option (right to buy) | |
| Dirk Thye | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.55 per share. | 16 Jan 2024 | 90,531 | 539,442 (1%) | 0% | 0.5 | 49,792 | Common Stock |
| Dirk Thye | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 149,999 | 450,001 | - | - | Employee Stock Option (right to buy) | |
| Thye Dirk | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 90,531 | 115,860 | - | - | Employee Stock Option (right to buy) | |
| Thye Dirk | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.94 per share. | 16 Jan 2024 | 149,999 | 689,441 (2%) | 0% | 0.9 | 140,999 | Common Stock |
| A. Lamond David | Director | Purchase of securities on an exchange or from another person at price $ 1.00 per share. | 12 Dec 2023 | 300 | 2,279,964 (7%) | 0% | 1 | 300 | Common Stock |
| David Lamond A. | Director | Purchase of securities on an exchange or from another person at price $ 1.04 per share. | 12 Dec 2023 | 22,627 | 2,347,545 (7%) | 0% | 1.0 | 23,532 | Common Stock |
| A. David Lamond | Director | Purchase of securities on an exchange or from another person at price $ 1.02 per share. | 12 Dec 2023 | 22,327 | 2,302,291 (7%) | 0% | 1.0 | 22,774 | Common Stock |
| A. David Lamond | Director | Purchase of securities on an exchange or from another person at price $ 1.00 per share. | 12 Dec 2023 | 22,627 | 2,324,918 (7%) | 0% | 1 | 22,627 | Common Stock |
| David Lamond A. | Director | Purchase of securities on an exchange or from another person at price $ 1.02 per share. | 05 Dec 2023 | 19,123 | 2,260,541 (7%) | 0% | 1.0 | 19,505 | Common Stock |
| Lamond A. David | Director | Purchase of securities on an exchange or from another person at price $ 1.01 per share. | 05 Dec 2023 | 19,123 | 2,279,664 (7%) | 0% | 1.0 | 19,314 | Common Stock |
| A. Lamond David | Director | Purchase of securities on an exchange or from another person at price $ 1.01 per share. | 05 Dec 2023 | 19,123 | 2,241,418 (7%) | 0% | 1.0 | 19,314 | Common Stock |
| David A. Lamond | Director | Purchase of securities on an exchange or from another person at price $ 1.32 per share. | 30 Aug 2023 | 41,026 | 2,179,161 (7%) | 0% | 1.3 | 54,154 | Common Stock |
| David A. Lamond | Director | Purchase of securities on an exchange or from another person at price $ 1.31 per share. | 30 Aug 2023 | 41,026 | 2,138,135 (7%) | 0% | 1.3 | 53,744 | Common Stock |
| David A. Lamond | Director | Purchase of securities on an exchange or from another person at price $ 1.32 per share. | 15 Aug 2023 | 107,886 | 1,954,995 (6%) | 0% | 1.3 | 142,410 | Common Stock |
| David A. Lamond | Director | Purchase of securities on an exchange or from another person at price $ 1.29 per share. | 15 Aug 2023 | 117,348 | 2,072,343 (7%) | 0% | 1.3 | 151,379 | Common Stock |
| David A. Lamond | Director | Purchase of securities on an exchange or from another person at price $ 1.29 per share. | 15 Aug 2023 | 24,766 | 2,097,109 (7%) | 0% | 1.3 | 31,948 | Common Stock |
| Dirk Thye | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 1.26 per share. | 10 Aug 2023 | 88,000 | 448,911 (1%) | 0% | 1.3 | 110,880 | Common Stock |
| Dirk Thye | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 1.24 per share. | 08 Aug 2023 | 80,000 | 360,911 (1%) | 0% | 1.2 | 99,200 | Common Stock |
| Margaret McLoughlin | Director | Purchase of securities on an exchange or from another person at price $ 1.23 per share. | 08 Aug 2023 | 8,000 | 8,000 (0%) | 0% | 1.2 | 9,840 | Common Stock |
| Brendan Hannah | Chief Business Officer | Purchase of securities on an exchange or from another person at price $ 1.22 per share. | 08 Aug 2023 | 71,762 | 201,555 (0%) | 0% | 1.2 | 87,550 | Common Stock |
| Una S. Ryan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2023 | 27,000 | 27,000 | - | - | Stock Option (right to buy) | |
| Christopher J. Senner | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2023 | 27,000 | 27,000 | - | - | Stock Option (right to buy) | |
| David A. Lamond | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2023 | 27,000 | 27,000 | - | - | Stock Option (right to buy) | |
| Margaret McLoughlin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2023 | 27,000 | 27,000 | - | - | Stock Option (right to buy) | |
| June Bray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2023 | 27,000 | 27,000 | - | - | Stock Option (right to buy) | |
| Ted Monohon | Chief Accounting Officer & VP | Sale of securities on an exchange or to another person at price $ 0.98 per share. | 06 Mar 2023 | 1,871 | 27,440 (0%) | 0% | 1.0 | 1,834 | Common Stock |
| Dirk Thye | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2023 | 600,000 | 600,000 | - | - | Employee Stock Option (right to buy) | |
| Karen L. Smith | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2023 | 225,000 | 225,000 | - | - | Employee Stock Option (right to buy) | |
| Ted Monohon | Chief Accounting Officer & VP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2023 | 110,000 | 110,000 | - | - | Employee Stock Option (right to buy) | |
| Brendan Hannah | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2023 | 225,000 | 225,000 | - | - | Employee Stock Option (right to buy) | |
| Ted Monohon | Chief Accounting Officer & VP | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.72 per share. | 05 Dec 2022 | 1,640 | 29,311 (0%) | 0% | 0.7 | 1,181 | Common Stock |
| Ted Monohon | Chief Accounting Officer & VP | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.64 per share. | 06 Sep 2022 | 1,520 | 30,951 (0%) | 0% | 1.6 | 2,493 | Common Stock |
| Ted Monohon | Chief Accounting Officer & VP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jun 2022 | 250,000 | 250,000 | - | - | Stock Option (right to buy) | |
| June Bray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2022 | 54,000 | 54,000 | - | - | Stock Option (right to buy) | |
| Una S. Ryan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2022 | 27,000 | 27,000 | - | - | Stock Option (right to buy) | |
| Christopher J. Senner | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2022 | 27,000 | 27,000 | - | - | Stock Option (right to buy) | |
| David A. Lamond | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2022 | 27,000 | 27,000 | - | - | Stock Option (right to buy) | |
| Margaret McLoughlin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2022 | 27,000 | 27,000 | - | - | Stock Option (right to buy) | |
| Caryn G. McDowell | Chief Legal & Adm. Officer | Sale of securities on an exchange or to another person at price $ 2.86 per share. | 06 Jun 2022 | 10,800 | 122,500 (0%) | 0% | 2.9 | 30,923 | Common Stock |
| Caryn G. McDowell | Chief Legal & Adm. Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.86 per share. | 06 Jun 2022 | 6,700 | 133,300 (0%) | 0% | 2.9 | 19,183 | Common Stock |
| Leslie Holsinger | EVP, Preclinical Development | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.86 per share. | 06 Jun 2022 | 10,920 | 148,080 (0%) | 0% | 2.9 | 31,231 | Common Stock |
| Ted Monohon | Chief Accounting Officer & VP | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.12 per share. | 06 Jun 2022 | 1,529 | 32,471 (0%) | 0% | 3.1 | 4,770 | Common Stock |
| Philip Low | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 May 2022 | 63,974 | 63,974 (0%) | 0% | - | Common Stock | |
| Philip Low | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 May 2022 | 455,309 | 455,309 (1%) | 1% | - | Common Stock | |
| Philip Low | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 May 2022 | 22,058 | 22,058 | - | - | Stock Option (right to buy) | |
| Dirk Thye | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 May 2022 | 216,322 | 280,911 (0%) | 0% | 0 | Common Stock | |
| Karen L. Smith | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 May 2022 | 170,354 | 194,690 (0%) | 0% | 0 | Common Stock | |
| David A. Lamond | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 May 2022 | 200,002 | 1,734,722 (5%) | 0% | - | Common Stock | |
| Brendan Hannah | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 May 2022 | 113,569 | 129,793 (0%) | 0% | 0 | Common Stock | |
| Marwan Noel Sabbagh | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2022 | 22,058 | 22,058 | - | - | Stock Option (right to buy) | |
| Christopher P. Lowe | Interim CEO, COO & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 175,000 | 265,000 (0%) | 0% | 0 | Common Stock | |
| Caryn G. McDowell | Chief Legal & Adm. Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 140,000 | 140,000 (0%) | 0% | 0 | Common Stock | |
| Michael Detke | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 140,000 | 140,000 (0%) | 0% | 0 | Common Stock | |
| Leslie Holsinger | EVP, Preclinical Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 155,500 | 159,000 (0%) | 0% | 0 | Common Stock | |
| Ted Monohon | Chief Accounting Officer & VP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 34,000 | 34,000 (0%) | 0% | 0 | Common Stock | |
| Christopher P. Lowe | COO & Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2022 | 125,000 | 125,000 | - | - | Stock Option (right to buy) | |
| Caryn G. McDowell | Chief Legal & Adm. Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2022 | 125,000 | 125,000 | - | - | Stock Option (right to buy) | |
| Casey C. Lynch | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2022 | 440,000 | 440,000 | - | - | Stock Option (right to buy) | |
| Michael Detke | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2022 | 125,000 | 125,000 | - | - | Stock Option (right to buy) | |
| Stephen S. Dominy | Director, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2022 | 125,000 | 125,000 | - | - | Stock Option (right to buy) | |
| Leslie Holsinger | EVP, R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2022 | 125,000 | 125,000 | - | - | Stock option (right to buy) | |
| Christopher P. Lowe | COO & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Nov 2021 | 30,000 | 103,294 | - | - | Stock Option (right to buy) | |
| Christopher P. Lowe | COO & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.23 per share. | 16 Nov 2021 | 30,000 | 90,000 (0%) | 0% | 2.2 | 66,900 | Common Stock |
| Margaret McLoughlin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.00 per share. | 08 Oct 2021 | 1,000 | 1,000 (0%) | 0% | 17 | 17,000 | Common Stock |
| Margaret McLoughlin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Oct 2021 | 1,000 | 84,911 | - | - | Stock Option (right to buy) | |
| Margaret McLoughlin | Director | Sale of securities on an exchange or to another person at price $ 88.93 per share. | 08 Oct 2021 | 1,000 | 0 (0%) | 0% | 88.9 | 88,930 | Common Stock |
| Christopher P. Lowe | COO & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 98.50 per share. | 05 Oct 2021 | 4,963 | 60,000 (0%) | 0% | 98.5 | 488,856 | Common Stock |
| Christopher P. Lowe | COO & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Oct 2021 | 4,963 | 95,037 | - | - | Stock Option (Right to Buy) | |
| Christopher P. Lowe | COO & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 54.85 per share. | 05 Oct 2021 | 4,963 | 64,963 (0%) | 0% | 54.9 | 272,221 | Common Stock |
| Christopher P. Lowe | COO & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.23 per share. | 16 Aug 2021 | 22,000 | 52,000 (0%) | 0% | 2.2 | 49,060 | Common Stock |
| Christopher P. Lowe | COO & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Aug 2021 | 22,000 | 163,294 | - | - | Stock Option (right to buy) | |
| Christopher P. Lowe | COO & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.23 per share. | 16 Aug 2021 | 30,000 | 60,000 (0%) | 0% | 2.2 | 66,900 | Common Stock |
| Christopher P. Lowe | COO & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 98.90 per share. | 16 Aug 2021 | 2,077 | 30,000 (0%) | 0% | 98.9 | 205,415 | Common Stock |
| Christopher P. Lowe | COO & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 97.28 per share. | 16 Aug 2021 | 1,100 | 32,077 (0%) | 0% | 97.3 | 107,008 | Common Stock |
| Christopher P. Lowe | COO & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 96.32 per share. | 16 Aug 2021 | 2,330 | 33,177 (0%) | 0% | 96.3 | 224,426 | Common Stock |
| Christopher P. Lowe | COO & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 95.02 per share. | 16 Aug 2021 | 7,335 | 35,507 (0%) | 0% | 95.0 | 696,972 | Common Stock |
| Christopher P. Lowe | COO & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 94.23 per share. | 16 Aug 2021 | 9,158 | 42,842 (0%) | 0% | 94.2 | 862,958 | Common Stock |
| Christopher P. Lowe | COO & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Aug 2021 | 30,000 | 133,294 | - | - | Stock Option (right to buy) | |
| Margaret McLoughlin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Aug 2021 | 6,000 | 85,911 | - | - | Stock Option (right to buy) | |
| Margaret McLoughlin | Director | Sale of securities on an exchange or to another person at price $ 98.90 per share. | 16 Aug 2021 | 48 | 0 (0%) | 0% | 98.9 | 4,747 | Common Stock |
| Margaret McLoughlin | Director | Sale of securities on an exchange or to another person at price $ 97.55 per share. | 16 Aug 2021 | 423 | 48 (0%) | 0% | 97.6 | 41,264 | Common Stock |
| Margaret McLoughlin | Director | Sale of securities on an exchange or to another person at price $ 96.51 per share. | 16 Aug 2021 | 1,429 | 471 (0%) | 0% | 96.5 | 137,913 | Common Stock |
| Margaret McLoughlin | Director | Sale of securities on an exchange or to another person at price $ 95.57 per share. | 16 Aug 2021 | 1,044 | 1,900 (0%) | 0% | 95.6 | 99,775 | Common Stock |
| Margaret McLoughlin | Director | Sale of securities on an exchange or to another person at price $ 94.55 per share. | 16 Aug 2021 | 3,056 | 2,944 (0%) | 0% | 94.6 | 288,945 | Common Stock |
| Margaret McLoughlin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.00 per share. | 16 Aug 2021 | 6,000 | 6,000 (0%) | 0% | 17 | 102,000 | Common Stock |
| Michael Detke | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Aug 2021 | 10,000 | 92,352 | - | - | Stock Option (right to buy) | |
| Michael Detke | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 100.00 per share. | 10 Aug 2021 | 10,000 | 0 (0%) | 0% | 100 | 1,000,000 | Common Stock |
| Michael Detke | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.23 per share. | 10 Aug 2021 | 10,000 | 10,000 (0%) | 0% | 2.2 | 22,300 | Common Stock |
| Michael Detke | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.23 per share. | 06 Jul 2021 | 12,600 | 40,861 (0%) | 0% | 2.2 | 28,098 | Common Stock |
| Michael Detke | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jul 2021 | 17,400 | 102,352 | - | - | Stock Option (right to buy) | |
| Michael Detke | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jul 2021 | 12,600 | 119,752 | - | - | Stock Option (right to buy) | |
| Michael Detke | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 56.99 per share. | 06 Jul 2021 | 523 | 0 (0%) | 0% | 57.0 | 29,806 | Common Stock |
| Michael Detke | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 56.27 per share. | 06 Jul 2021 | 6,942 | 523 (0%) | 0% | 56.3 | 390,626 | Common Stock |
| Michael Detke | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 55.38 per share. | 06 Jul 2021 | 4,353 | 7,465 (0%) | 0% | 55.4 | 241,069 | Common Stock |
| Michael Detke | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 54.37 per share. | 06 Jul 2021 | 1,648 | 11,818 (0%) | 0% | 54.4 | 89,602 | Common Stock |
| Michael Detke | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 53.24 per share. | 06 Jul 2021 | 3,934 | 13,466 (0%) | 0% | 53.2 | 209,446 | Common Stock |
| Michael Detke | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.23 per share. | 06 Jul 2021 | 17,400 | 17,400 (0%) | 0% | 2.2 | 38,802 | Common Stock |
| Michael Detke | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 55.01 per share. | 06 Jul 2021 | 288 | 0 (0%) | 0% | 55.0 | 15,843 | Common Stock |
| Michael Detke | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 53.91 per share. | 06 Jul 2021 | 8,260 | 288 (0%) | 0% | 53.9 | 445,297 | Common Stock |
| Michael Detke | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 53.43 per share. | 06 Jul 2021 | 32,313 | 8,548 (0%) | 0% | 53.4 | 1,726,484 | Common Stock |
| Christopher P. Lowe | COO & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 53.39 per share. | 28 Jun 2021 | 7,724 | 12,276 (0%) | 0% | 53.4 | 412,384 | Common Stock |
| Christopher P. Lowe | COO & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Jun 2021 | 30,000 | 185,294 | - | - | Stock Option (right to buy) | |
| Christopher P. Lowe | COO & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Jun 2021 | 20,000 | 215,594 | - | - | Stock Option (right to buy) | |
| Christopher P. Lowe | COO & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.23 per share. | 28 Jun 2021 | 30,000 | 30,000 (0%) | 0% | 2.2 | 66,900 | Common Stock |
| Christopher P. Lowe | COO & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 56.16 per share. | 28 Jun 2021 | 1,044 | 0 (0%) | 0% | 56.2 | 58,631 | Common Stock |
| Christopher P. Lowe | COO & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 55.11 per share. | 28 Jun 2021 | 4,153 | 1,044 (0%) | 0% | 55.1 | 228,872 | Common Stock |
| Christopher P. Lowe | COO & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 54.13 per share. | 28 Jun 2021 | 7,079 | 5,197 (0%) | 0% | 54.1 | 383,186 | Common Stock |
| Christopher P. Lowe | COO & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.23 per share. | 28 Jun 2021 | 20,000 | 20,000 (0%) | 0% | 2.2 | 44,600 | Common Stock |
| Margaret McLoughlin | Director | Sale of securities on an exchange or to another person at price $ 55.03 per share. | 28 Jun 2021 | 250 | 100 (0%) | 0% | 55.0 | 13,758 | Common Stock |
| Margaret McLoughlin | Director | Sale of securities on an exchange or to another person at price $ 55.73 per share. | 28 Jun 2021 | 100 | 0 (0%) | 0% | 55.7 | 5,573 | Common Stock |
| Margaret McLoughlin | Director | Sale of securities on an exchange or to another person at price $ 55.01 per share. | 28 Jun 2021 | 200 | 350 (0%) | 0% | 55.0 | 11,002 | Common Stock |
| Una S. Ryan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2021 | 11,029 | 11,029 | - | - | Stock Option (right to buy) | |
| Christopher J. Senner | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2021 | 11,029 | 11,029 | - | - | Stock Option (right to buy) | |
| David A. Lamond | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2021 | 11,029 | 11,029 | - | - | Stock Option (right to buy) | |
| Margaret McLoughlin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2021 | 11,029 | 11,029 | - | - | Stock Option (right to buy) | |
| Casey C. Lynch | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 36.73 per share. | 10 May 2021 | 183 | 978,774 (3%) | 0% | 36.7 | 6,722 | Common Stock |
| Casey C. Lynch | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 35.81 per share. | 10 May 2021 | 6,315 | 978,957 (3%) | 0% | 35.8 | 226,140 | Common Stock |
| Casey C. Lynch | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 33.75 per share. | 10 May 2021 | 13,584 | 995,190 (3%) | 0% | 33.8 | 458,460 | Common Stock |
| Casey C. Lynch | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 34.89 per share. | 10 May 2021 | 9,918 | 985,272 (3%) | 0% | 34.9 | 346,039 | Common Stock |
| David A. Lamond | Director | Purchase of securities on an exchange or from another person at price $ 33.77 per share. | 24 Mar 2021 | 50,000 | 1,847,109 (6%) | 0% | 33.8 | 1,688,500 | Common Stock |
| Casey C. Lynch | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 36.58 per share. | 22 Mar 2021 | 300 | 1,009,174 (3%) | 0% | 36.6 | 10,974 | Common Stock |
| Casey C. Lynch | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 35.85 per share. | 22 Mar 2021 | 18,089 | 1,009,474 (3%) | 0% | 35.9 | 648,491 | Common Stock |
| Casey C. Lynch | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 35.10 per share. | 22 Mar 2021 | 11,211 | 1,027,563 (3%) | 0% | 35.1 | 393,506 | Common Stock |
| Casey C. Lynch | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 36.60 per share. | 22 Mar 2021 | 400 | 1,008,774 (3%) | 0% | 36.6 | 14,640 | Common Stock |
| David A. Lamond | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 04 Mar 2021 | 1,534,720 | 1,534,720 (5%) | 5% | 0 | Common Stock | |
| David A. Lamond | Director | Purchase of securities on an exchange or from another person at price $ 36.86 per share. | 04 Mar 2021 | 4,100 | 1,797,109 (6%) | 0% | 36.9 | 151,126 | Common Stock |
| David A. Lamond | Director | Purchase of securities on an exchange or from another person at price $ 36.34 per share. | 04 Mar 2021 | 15,969 | 1,793,009 (6%) | 0% | 36.3 | 580,313 | Common Stock |
| David A. Lamond | Director | Purchase of securities on an exchange or from another person at price $ 35.00 per share. | 04 Mar 2021 | 13,310 | 1,777,040 (6%) | 0% | 35 | 465,850 | Common Stock |
| David A. Lamond | Director | Purchase of securities on an exchange or from another person at price $ 34.28 per share. | 04 Mar 2021 | 16,621 | 1,763,730 (6%) | 0% | 34.3 | 569,768 | Common Stock |
| Christopher P. Lowe | COO & Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2021 | 40,000 | 40,000 | - | - | Employee Stock Option (right to buy) | |
| Ted Monohon | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2021 | 20,000 | 20,000 | - | - | Employee Stock Option (right to buy) | |
| Casey C. Lynch | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 44.22 per share. | 01 Feb 2021 | 1,900 | 1,047,406 (3%) | 0% | 44.2 | 84,018 | Common Stock |
| Casey C. Lynch | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 43.10 per share. | 01 Feb 2021 | 1,512 | 1,049,306 (3%) | 0% | 43.1 | 65,167 | Common Stock |
| Casey C. Lynch | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 41.91 per share. | 01 Feb 2021 | 3,100 | 1,050,818 (3%) | 0% | 41.9 | 129,921 | Common Stock |
| Casey C. Lynch | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 40.84 per share. | 01 Feb 2021 | 2,000 | 1,053,918 (3%) | 0% | 40.8 | 81,680 | Common Stock |
| Casey C. Lynch | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 39.82 per share. | 01 Feb 2021 | 856 | 1,055,918 (3%) | 0% | 39.8 | 34,086 | Common Stock |
| Casey C. Lynch | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 38.64 per share. | 01 Feb 2021 | 1,600 | 1,056,774 (3%) | 0% | 38.6 | 61,824 | Common Stock |
| Casey C. Lynch | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 37.39 per share. | 01 Feb 2021 | 400 | 1,058,374 (3%) | 0% | 37.4 | 14,956 | Common Stock |
| Casey C. Lynch | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 36.75 per share. | 01 Feb 2021 | 5,071 | 1,058,774 (3%) | 0% | 36.7 | 186,359 | Common Stock |
| Casey C. Lynch | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 36.02 per share. | 01 Feb 2021 | 14,929 | 1,063,845 (3%) | 0% | 36.0 | 537,743 | Common Stock |
| Casey C. Lynch | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 34.60 per share. | 01 Feb 2021 | 4,686 | 1,094,088 (3%) | 0% | 34.6 | 162,136 | Common Stock |
| Casey C. Lynch | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 39.23 per share. | 01 Feb 2021 | 371 | 1,078,774 (3%) | 0% | 39.2 | 14,554 | Common Stock |
| Casey C. Lynch | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 38.28 per share. | 01 Feb 2021 | 100 | 1,079,145 (3%) | 0% | 38.3 | 3,828 | Common Stock |
| Casey C. Lynch | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 37.68 per share. | 01 Feb 2021 | 4,283 | 1,079,245 (3%) | 0% | 37.7 | 161,383 | Common Stock |
| Casey C. Lynch | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 35.59 per share. | 01 Feb 2021 | 3,100 | 1,090,988 (3%) | 0% | 35.6 | 110,329 | Common Stock |
| Casey C. Lynch | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 36.56 per share. | 01 Feb 2021 | 7,460 | 1,083,528 (3%) | 0% | 36.6 | 272,738 | Common Stock |
| Casey C. Lynch | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 45.73 per share. | 01 Feb 2021 | 600 | 1,038,774 (3%) | 0% | 45.7 | 27,438 | Common Stock |
| Casey C. Lynch | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 45.00 per share. | 01 Feb 2021 | 8,032 | 1,039,374 (3%) | 0% | 45 | 361,440 | Common Stock |
| Christopher P. Lowe | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Dec 2020 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Christopher P. Lowe | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Dec 2020 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Caryn G. McDowell | Chief Legal & Adm. Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Dec 2020 | 75,000 | 75,000 | - | - | Stock Option (Right to Buy) | |
| Caryn G. McDowell | Chief Legal & Adm. Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Dec 2020 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Casey C. Lynch | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Dec 2020 | 175,000 | 175,000 | - | - | Stock Option (Right to Buy) | |
| Casey C. Lynch | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Dec 2020 | 175,000 | 175,000 | - | - | Stock Option (Right to Buy) | |
| Michael Detke | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Dec 2020 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Michael Detke | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Dec 2020 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Stephen S. Dominy | Director, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Dec 2020 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Stephen S. Dominy | Director, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Dec 2020 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Leslie Holsinger | Executive Vice President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Dec 2020 | 40,000 | 66,794 | - | - | Stock Option (Right to Buy) | |
| Leslie Holsinger | Executive Vice President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Dec 2020 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Leslie Holsinger | Executive Vice President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Dec 2020 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Leslie Holsinger | Executive Vice President | Sale of securities on an exchange or to another person at price $ 32.59 per share. | 11 Dec 2020 | 900 | 3,500 (0%) | 0% | 32.6 | 29,331 | Common Stock |
| Leslie Holsinger | Executive Vice President | Sale of securities on an exchange or to another person at price $ 32.58 per share. | 11 Dec 2020 | 400 | 4,400 (0%) | 0% | 32.6 | 13,034 | Common Stock |
| Leslie Holsinger | Executive Vice President | Sale of securities on an exchange or to another person at price $ 31.79 per share. | 11 Dec 2020 | 9,525 | 1,800 (0%) | 0% | 31.8 | 302,800 | Common Stock |
| Leslie Holsinger | Executive Vice President | Sale of securities on an exchange or to another person at price $ 30.91 per share. | 11 Dec 2020 | 13,200 | 14,325 (0%) | 0% | 30.9 | 408,012 | Common Stock |
| Leslie Holsinger | Executive Vice President | Sale of securities on an exchange or to another person at price $ 30.15 per share. | 11 Dec 2020 | 14,275 | 27,525 (0%) | 0% | 30.1 | 430,391 | Common Stock |
| Leslie Holsinger | Executive Vice President | Sale of securities on an exchange or to another person at price $ 28.80 per share. | 11 Dec 2020 | 1,700 | 41,800 (0%) | 0% | 28.8 | 48,960 | Common Stock |
| Leslie Holsinger | Executive Vice President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.27 per share. | 11 Dec 2020 | 40,000 | 43,500 (0%) | 0% | 0.3 | 10,800 | Common Stock |
| Leslie Holsinger | Executive Vice President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Dec 2020 | 3,500 | 106,794 | - | - | Stock Option (Right to Buy) | |
| Leslie Holsinger | Executive Vice President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.27 per share. | 10 Dec 2020 | 3,500 | 3,500 (0%) | 0% | 0.3 | 945 | Common Stock |
| Una S. Ryan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2020 | 11,029 | 11,029 | - | - | Stock Option (Right to Buy) | |
| Kevin Young | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2020 | 11,029 | 11,029 | - | - | Stock Option (Right to Buy) | |
| Christopher J. Senner | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2020 | 11,029 | 11,029 | - | - | Stock Option (Right to Buy) | |
| David A. Lamond | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2020 | 11,029 | 11,029 | - | - | Stock Option (Right to Buy) | |
| Margaret McLoughlin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2020 | 11,029 | 11,029 | - | - | Stock Option (Right to Buy) | |
| David A. Lamond | Director | Purchase of securities on an exchange or from another person at price $ 43.88 per share. | 04 Jun 2020 | 24,874 | 1,747,109 (5%) | 0% | 43.9 | 1,091,384 | Common Stock |
| David A. Lamond | Director | Purchase of securities on an exchange or from another person at price $ 42.13 per share. | 04 Jun 2020 | 13,609 | 1,711,593 (5%) | 0% | 42.1 | 573,377 | Common Stock |
| David A. Lamond | Director | Purchase of securities on an exchange or from another person at price $ 43.32 per share. | 04 Jun 2020 | 10,642 | 1,722,235 (5%) | 0% | 43.3 | 461,034 | Common Stock |
| Michael Detke | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.91 per share. | 27 May 2020 | 5,515 | 28,261 (0%) | 0% | 6.9 | 38,109 | Common Stock |
| Michael Detke | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 May 2020 | 5,515 | 104,091 | - | - | Stock Option (Right to Buy) | |
| David A. Lamond | Director | Purchase of securities on an exchange or from another person at price $ 56.42 per share. | 15 May 2020 | 32,894 | 1,697,984 (5%) | 0% | 56.4 | 1,855,738 | Common Stock |
| David A. Lamond | Director | Purchase of securities on an exchange or from another person at price $ 55.42 per share. | 15 May 2020 | 5,906 | 1,665,090 (5%) | 0% | 55.4 | 327,309 | Common Stock |
| David A. Lamond | Director | Purchase of securities on an exchange or from another person at price $ 54.09 per share. | 15 May 2020 | 400 | 1,659,184 (5%) | 0% | 54.1 | 21,636 | Common Stock |
| David A. Lamond | Director | Purchase of securities on an exchange or from another person at price $ 53.10 per share. | 15 May 2020 | 100 | 1,658,784 (5%) | 0% | 53.1 | 5,310 | Common Stock |
| David A. Lamond | Director | Purchase of securities on an exchange or from another person at price $ 52.20 per share. | 15 May 2020 | 500 | 1,658,684 (5%) | 0% | 52.2 | 26,101 | Common Stock |
| David A. Lamond | Director | Purchase of securities on an exchange or from another person at price $ 50.71 per share. | 15 May 2020 | 1,000 | 1,658,184 (5%) | 0% | 50.7 | 50,707 | Common Stock |
| David A. Lamond | Director | Purchase of securities on an exchange or from another person at price $ 48.96 per share. | 15 May 2020 | 1,600 | 1,657,184 (5%) | 0% | 49.0 | 78,333 | Common Stock |
| David A. Lamond | Director | Purchase of securities on an exchange or from another person at price $ 46.30 per share. | 15 May 2020 | 1,263 | 1,654,599 (5%) | 0% | 46.3 | 58,478 | Common Stock |
| David A. Lamond | Director | Purchase of securities on an exchange or from another person at price $ 48.37 per share. | 15 May 2020 | 985 | 1,655,584 (5%) | 0% | 48.4 | 47,640 | Common Stock |
| Christopher P. Lowe | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2020 | 30,000 | 30,000 | - | - | Stock Option (Right to Buy) | |
| Caryn G. McDowell | Chief Legal & Adm. Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2020 | 200,000 | 200,000 | - | - | Stock Option (Right to Buy) | |
| Leslie Holsinger | Executive Vice President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2020 | 30,000 | 30,000 | - | - | Stock Option (Right to Buy) | |
| Michael Detke | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Apr 2020 | 5,515 | 109,606 | - | - | Stock Option (Right to Buy) | |
| Michael Detke | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.91 per share. | 02 Apr 2020 | 5,515 | 22,746 (0%) | 0% | 6.9 | 38,109 | Common Stock |
| David A. Lamond | Director | Grant, award, or other acquisition of securities at price $ 50.00 per share. | 10 Feb 2020 | 30,000 | 1,653,336 (5%) | 0% | 50 | 1,500,000 | Common Stock |
| Christopher P. Lowe | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2020 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Casey C. Lynch | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2020 | 175,000 | 175,000 | - | - | Stock Option (Right to Buy) | |
| Kristen Gafric | SVP, Legal & Administration | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2020 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Michael Detke | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2020 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Michael Detke | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.91 per share. | 06 Feb 2020 | 17,231 | 17,231 (0%) | 0% | 6.9 | 119,066 | Common Stock |
| Michael Detke | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Feb 2020 | 17,231 | 115,121 | - | - | Stock Option (Right to Buy) | |
| Stephen S. Dominy | Director, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2020 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Leslie Holsinger | Executive Vice President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2020 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Kristen Gafric | SVP, Legal & Administration | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Aug 2019 | 75,000 | 75,000 | - | - | Employee Stock Option (Right to Buy) | |
| Una S. Ryan | Director | Purchase of securities on an exchange or from another person at price $ 17.00 per share. | 13 May 2019 | 2,875 | 2,875 (0%) | 0% | 17 | 48,875 | Common Stock |
| Kevin Young | Director | Purchase of securities on an exchange or from another person at price $ 17.00 per share. | 13 May 2019 | 30,000 | 30,000 (0%) | 0% | 17 | 510,000 | Common Stock |
| David A. Lamond | Director | 13 May 2019 | 301,829 | 301,829 (1%) | 1% | - | Common Stock | ||
| David A. Lamond | Director | 13 May 2019 | 924,056 | 0 | - | - | Series B Redeemable Convertible Preferred Stock | ||
| David A. Lamond | Director | 13 May 2019 | 301,829 | 0 | - | - | Series A Redeemable Convertible Preferred Stock | ||
| David A. Lamond | Director | 13 May 2019 | 699,280 | 0 | - | - | Series A Redeemable Convertible Preferred Stock | ||
| David A. Lamond | Director | 13 May 2019 | 1,623,336 | 1,623,336 (5%) | 6% | - | Common Stock | ||
| Margaret McLoughlin | Director | Purchase of securities on an exchange or from another person at price $ 17.00 per share. | 13 May 2019 | 550 | 550 (0%) | 0% | 17 | 9,350 | Common Stock |
| Margaret McLoughlin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2019 | 91,911 | 91,911 | - | - | Stock Option (Right to buy) |